Inhibition of T cell proliferation by human alveolar macrophages
نویسندگان
چکیده
منابع مشابه
Inhibition of T cell proliferation by human alveolar macrophages.
The demonstration by Upham et al that human alveolar macrophages selectively inhibit proliferation of T cells by secretion of unidentified eVector molecules raises the question as to whether pathological processes in the lung characterised by extensive macrophage recruitment or activation can have a systemic eVect on T cell development. It has been shown in several studies that patients with pu...
متن کاملSelective inhibition of T cell proliferation but not expression of effector function by human alveolar macrophages.
BACKGROUND Alveolar macrophages are thought to play an important part in regulating lung immune responses. While it is clear that human alveolar macrophages suppress T cell proliferation in vitro, the mechanisms by which this is achieved are not clear, nor is it known whether alveolar macrophages also inhibit other aspects of T cell function. METHODS Peripheral blood mononuclear cells were st...
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Tissue- and organ-specific factors may be important in the regulation of cytotoxic lymphocytes. We therefore examined the ability of human alveolar macrophages (AMs) to alter the tumoricidal function of lymphokine-activated killer cells (LAK cells). AMs, obtained by bronchoalveolar lavage from healthy volunteers, or peripheral blood monocytes were added to a standard 4-h chromium release LAK as...
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Background MicroRNAs are small and non-coding RNA molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mRNA. MiR-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. One of its best known functions is apoptosis that affects on caspase-3 activity. The main aim...
متن کاملSuppression of T-cell activation by pulmonary alveolar macrophages: dissociation of effects on TcR, IL-2R expression, and proliferation.
Suppression of local T-cell activation in the lower respiratory tract by resident pulmonary alveolar macrophages (PAMs) is believed to play an important role in the maintenance of local immunological homeostasis. However, the mechanism(s) by which pulmonary alveolar macrophages regulate T-cell responses are poorly characterized. The present study examines early events during the activation proc...
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ژورنال
عنوان ژورنال: Thorax
سال: 1998
ISSN: 0040-6376
DOI: 10.1136/thx.53.5.437